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    Update on treatment options for advanced bile duct tumours: radioembolisation for advanced cholangiocarcinoma.

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    10.1007%2Fs11912-017-0603-8.pdf
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    Authors
    Najran, Pavan
    Lamarca, Angela
    Mullan, Damian
    McNamara, Mairéad G
    Westwood, Thomas D
    Hubner, Richard A
    Lawrance, Jeremy A L
    Manoharan, Prakash
    Bell, Jon
    Valle, Juan W
    Affiliation
    Department of Radiology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2017-07
    
    Metadata
    Show full item record
    Abstract
    Cholangiocarcinoma is a rare form of gastrointestinal cancer with a poor prognosis. Patients often present with biliary obstruction or non-specific abdominal pain, and a high proportion of patients have advanced disease at initial diagnosis. The goal of this review is to discuss treatment options for patients with advanced bile duct tumours focusing on radioembolisation (RE) and its impact on overall survival. RE provides a therapeutic option for patients with unresectable cholangiocarcinoma. However, although systemic chemotherapy has demonstrated a survival benefit in randomised controlled trials, there is limited supporting evidence for the use of RE in this setting. Studies are mostly limited to single-centre, small cohorts with variable outcome measures. Additionally, patients included in these studies received a variety of previous therapies including chemotherapy, surgery or alternative intra-arterial therapy; therefore, a true assessment of overall survival benefit is difficult.
    Citation
    Update on treatment options for advanced bile duct tumours: radioembolisation for advanced cholangiocarcinoma. 2017, 19 (7):50 Curr Oncol Rep
    Journal
    Current Oncology Reports
    URI
    http://hdl.handle.net/10541/620501
    DOI
    10.1007/s11912-017-0603-8
    PubMed ID
    28656502
    Type
    Article
    Language
    en
    ISSN
    1534-6269
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11912-017-0603-8
    Scopus Count
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