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    EGFR T790M mutation testing within the osimertinib AURA phase I study.

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    Authors
    Dearden, S
    Brown, H
    Jenkins, S
    Thress, K
    Cantarini, M
    Cole, R
    Ranson, Malcolm R
    Jänne, P
    Affiliation
    Personalised Healthcare & Biomarkers, AstraZeneca, Cambridge
    Issue Date
    2017-07
    
    Metadata
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    Abstract
    Reliable epidermal growth factor receptor (EGFR) mutation testing techniques are required to identify eligible patients with EGFR mutation/T790M positive advanced non-small cell lung cancer (NSCLC), for treatment with osimertinib (AZD9291), an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR-TKI-sensitizing and T790M resistance mutations over wild-type EGFR. There is no current consensus regarding the best method to detect EGFR T790M mutations. The aim of this study was to describe the concordance between local testing, which used a variety of methods, and central testing, using the cobas(®) EGFR Mutation Test, for EGFR-sensitizing mutations and the T790M resistance mutation.
    Citation
    EGFR T790M mutation testing within the osimertinib AURA phase I study. 2017, 109:9-13 Lung Cancer
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/620462
    DOI
    10.1016/j.lungcan.2017.04.011
    PubMed ID
    28577957
    Type
    Article
    Language
    en
    ISSN
    1872-8332
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.lungcan.2017.04.011
    Scopus Count
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