AffiliationClinical Research Fellow, Division of Cancer Sciences, School of Medical Sciences Faculty of Biology, Medicine and Health, University of Manchester
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AbstractWe would like to draw attention of the readership to the problems associated with outcome heterogeneity in clinical trials, with particular reference to anal cancer. Outcome heterogeneity, and the related issue of reporting outcome bias, is a barrier to evidence synthesis  , particularly in rare diseases where few randomised trials are published. A recent review  of trials of chemoradiation for anal squamous cell carcinoma (ASCC) highlights the heterogeneity observed in reporting outcomes and calls for the development of a core set of outcomes. This article is protected by copyright. All rights reserved.
CitationCore outcome research measures in anal cancer. 2017 Colorectal Dis