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    Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway.

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    Authors
    Peiró, C
    Romacho, T
    Azcutia, V
    Villalobos, L
    Fernández, E
    Bolaños, J
    Moncada, Salvador
    Sánchez-Ferrer, C
    Affiliation
    Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, 29029, Madrid
    Issue Date
    2016-06-01
    
    Metadata
    Show full item record
    Abstract
    Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cells previously primed with pro-inflammatory stimuli, such as the cytokine interleukin (IL)1β. Here, we aimed to identify the cellular mechanisms by which high glucose exacerbates the vascular inflammation induced by IL1β.
    Citation
    Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. 2016, 15:82 Cardiovasc Diabetol
    Journal
    Cardiovascular Diabetology
    URI
    http://hdl.handle.net/10541/620430
    DOI
    10.1186/s12933-016-0397-2
    PubMed ID
    27245224
    Type
    Article
    Language
    en
    ISSN
    1475-2840
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12933-016-0397-2
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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