Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway.
AffiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, 29029, Madrid
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AbstractHyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cells previously primed with pro-inflammatory stimuli, such as the cytokine interleukin (IL)1β. Here, we aimed to identify the cellular mechanisms by which high glucose exacerbates the vascular inflammation induced by IL1β.
CitationInflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. 2016, 15:82 Cardiovasc Diabetol
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