Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway.
Authors
Peiró, CRomacho, T
Azcutia, V
Villalobos, L
Fernández, E
Bolaños, J
Moncada, Salvador
Sánchez-Ferrer, C
Affiliation
Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, 29029, MadridIssue Date
2016-06-01
Metadata
Show full item recordAbstract
Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cells previously primed with pro-inflammatory stimuli, such as the cytokine interleukin (IL)1β. Here, we aimed to identify the cellular mechanisms by which high glucose exacerbates the vascular inflammation induced by IL1β.Citation
Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. 2016, 15:82 Cardiovasc DiabetolJournal
Cardiovascular DiabetologyDOI
10.1186/s12933-016-0397-2PubMed ID
27245224Type
ArticleLanguage
enISSN
1475-2840ae974a485f413a2113503eed53cd6c53
10.1186/s12933-016-0397-2
Scopus Count
Collections
Related articles
- The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats.
- Authors: Vallejo S, Palacios E, Romacho T, Villalobos L, Peiró C, Sánchez-Ferrer CF
- Issue date: 2014 Dec 18
- A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.
- Authors: Iizumi T, Takahashi S, Mashima K, Minami K, Izawa Y, Abe T, Hishiki T, Suematsu M, Kajimura M, Suzuki N
- Issue date: 2016 May 4
- Pyruvate improves deleterious effects of high glucose on activation of pentose phosphate pathway and glutathione redox cycle in endothelial cells.
- Authors: Kashiwagi A, Nishio Y, Asahina T, Ikebuchi M, Harada N, Tanaka Y, Takahara N, Taki H, Obata T, Hidaka H, Saeki Y, Kikkawa R
- Issue date: 1997 Dec
- Arginine attenuates methylglyoxal- and high glucose-induced endothelial dysfunction and oxidative stress by an endothelial nitric-oxide synthase-independent mechanism.
- Authors: Dhar I, Dhar A, Wu L, Desai K
- Issue date: 2012 Jul
- NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
- Authors: Balteau M, Tajeddine N, de Meester C, Ginion A, Des Rosiers C, Brady NR, Sommereyns C, Horman S, Vanoverschelde JL, Gailly P, Hue L, Bertrand L, Beauloye C
- Issue date: 2011 Nov 1