Pathology update to the Manchester Scoring System based on testing in over 4000 families.

Authors
Evans, D Gareth R
Harkness, E
Plaskocinska, I
Wallace, A
Clancy, T
Woodward, E
Howell, Anthony
Tischkowitz, M
Lalloo, F
Affiliation
Prevent Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, UK
Issue Date
2017-05-10

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Abstract
While the requirement for thresholds for testing for mutations in BRCA1/2 is being questioned, they are likely to remain for individuals unaffected by a relevant cancer. It is still useful to provide pretesting likelihoods, but models need to take into account tumour pathology.
Citation
Pathology update to the Manchester Scoring System based on testing in over 4000 families. 2017 J Med Genet
Journal
Journal of Medical Genetics
URI
http://hdl.handle.net/10541/620405
DOI
10.1136/jmedgenet-2017-104584
PubMed ID
28490612
Type
Article
Language
en
ISSN
1468-6244
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