Pathology update to the Manchester Scoring System based on testing in over 4000 families.
AuthorsEvans, D Gareth R
AffiliationPrevent Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, UK
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AbstractWhile the requirement for thresholds for testing for mutations in BRCA1/2 is being questioned, they are likely to remain for individuals unaffected by a relevant cancer. It is still useful to provide pretesting likelihoods, but models need to take into account tumour pathology.
CitationPathology update to the Manchester Scoring System based on testing in over 4000 families. 2017 J Med Genet
JournalJournal of Medical Genetics