Show simple item record

dc.contributor.authorGalkin, A
dc.contributor.authorMoncada, Salvador
dc.date.accessioned2017-05-12T12:41:09Z
dc.date.available2017-05-12T12:41:09Z
dc.date.issued2017-04-06
dc.identifier.citationModulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. 2017, 7 (2):20160104 Interface Focusen
dc.identifier.issn2042-8898
dc.identifier.pmid28382200
dc.identifier.doi10.1098/rsfs.2016.0104
dc.identifier.urihttp://hdl.handle.net/10541/620361
dc.description.abstractIn recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.
dc.language.isoenen
dc.rightsArchived with thanks to Interface focusen
dc.titleModulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.en
dc.typeArticleen
dc.contributor.departmentFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, 401 East 61st Street, 5th floor, New York, NY 10065, USAen
dc.identifier.journalInterface Focusen
html.description.abstractIn recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.


This item appears in the following Collection(s)

Show simple item record