Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.
AffiliationFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, 401 East 61st Street, 5th floor, New York, NY 10065, USA
MetadataShow full item record
AbstractIn recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.
CitationModulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. 2017, 7 (2):20160104 Interface Focus
- Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I.
- Authors: Babot M, Galkin A
- Issue date: 2013 Oct
- Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia.
- Authors: Gorenkova N, Robinson E, Grieve DJ, Galkin A
- Issue date: 2013 Nov 1
- Characterisation of the active/de-active transition of mitochondrial complex I.
- Authors: Babot M, Birch A, Labarbuta P, Galkin A
- Issue date: 2014 Jul
- Ischemic A/D transition of mitochondrial complex I and its role in ROS generation.
- Authors: Dröse S, Stepanova A, Galkin A
- Issue date: 2016 Jul
- Understanding and preventing mitochondrial oxidative damage.
- Authors: Murphy MP
- Issue date: 2016 Oct 15