The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant K(trans) in cervical cancer is explained by plasma flow rather than vessel permeability.
Authors
Dickie, Ben RRose, C
Kershaw, Lucy E
Withey, S
Carrington, Bernadette M
Davidson, Susan E
Hutchison, G
West, Catharine M L
Affiliation
Division of Molecular and Clinical Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4BX, UKIssue Date
2017-04-27
Metadata
Show full item recordAbstract
The microvascular contrast agent transfer constant K(trans) has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to K(trans) of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both.Citation
The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant K(trans) in cervical cancer is explained by plasma flow rather than vessel permeability. 2017 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2017.121PubMed ID
28449009Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2017.121
Scopus Count
Collections
Related articles
- DCE-MRI of locally-advanced carcinoma of the uterine cervix: Tofts analysis versus non-model-based analyses.
- Authors: Lund KV, Simonsen TG, Kristensen GB, Rofstad EK
- Issue date: 2020 Apr 15
- Flow versus permeability weighting in estimating the forward volumetric transfer constant (K<sup>trans</sup>) obtained by DCE-MRI with contrast agents of differing molecular sizes.
- Authors: Li CH, Chen FH, Schellingerhout D, Lin YS, Hong JH, Liu HL
- Issue date: 2017 Feb
- Assessment of vessel permeability by combining dynamic contrast-enhanced and arterial spin labeling MRI.
- Authors: Liu HL, Chang TT, Yan FX, Li CH, Lin YS, Wong AM
- Issue date: 2015 Jun
- Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome.
- Authors: Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E
- Issue date: 2013 Apr
- Voxelwise comparison of perfusion parameters estimated using dynamic contrast enhanced (DCE) computed tomography and DCE-magnetic resonance imaging in locally advanced cervical cancer.
- Authors: Kallehauge J, Nielsen T, Haack S, Peters DA, Mohamed S, Fokdal L, Lindegaard JC, Hansen DC, Rasmussen F, Tanderup K, Pedersen EM
- Issue date: 2013 Oct