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dc.contributor.authorSyed Khaja, A
dc.contributor.authorToor, S
dc.contributor.authorEl Salhat, H
dc.contributor.authorFaour, I
dc.contributor.authorUl Haq, N
dc.contributor.authorAli, B
dc.contributor.authorElkord, Eyad
dc.date.accessioned2017-05-12T12:19:51Z
dc.date.available2017-05-12T12:19:51Z
dc.date.issued2017
dc.identifier.citationPreferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment. 2017 Oncotargeten
dc.identifier.issn1949-2553
dc.identifier.pmid28388539
dc.identifier.doi10.18632/oncotarget.16565
dc.identifier.urihttp://hdl.handle.net/10541/620351
dc.description.abstractImmunosuppressive cells such as regulatory T cells (Tregs) have an ambiguous role in breast cancer prognosis, with studies reporting both positive and negative correlations between Treg infiltration and prognosis. This discrepancy could be due to the different immunosuppressive molecules present in these cells. In the present study, we phenotypically characterize different Treg subsets infiltrating the tumor microenvironment (TME), compared to adjacent normal tissue and peripheral blood of primary breast cancer (PBC) patients. We report that the majority of tumor-infiltrating CD4+ and CD8+ T cells have terminally exhaustive phenotype as assessed by CD39 and PD-1 expressions. We also show that Tregs are accumulated in breast TME compared to normal tissue. Further characterization of Tregs showed that these are mainly FoxP3+Helios+ and express high levels of CTLA-4 and PD-1. This preferential accumulation of FoxP3+Helios+ Treg subset with co-expression of different immune inhibitory molecules might have a negative effect on breast cancer prognosis. Taken together, our results suggest that breast tumor cells might utilize Tregs, and different suppressive pathways involving CD39, PD-1 and CTLA-4 molecules in creating an immune-subversive environment for them to survive, and a dual blockade of these immunosuppressive molecules might be considered as an effective method in breast cancer treatment.
dc.language.isoenen
dc.rightsArchived with thanks to Oncotargeten
dc.titlePreferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment.en
dc.typeArticleen
dc.contributor.departmentCancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qataren
dc.identifier.journalOncotargeten
refterms.dateFOA2018-12-17T14:55:08Z
html.description.abstractImmunosuppressive cells such as regulatory T cells (Tregs) have an ambiguous role in breast cancer prognosis, with studies reporting both positive and negative correlations between Treg infiltration and prognosis. This discrepancy could be due to the different immunosuppressive molecules present in these cells. In the present study, we phenotypically characterize different Treg subsets infiltrating the tumor microenvironment (TME), compared to adjacent normal tissue and peripheral blood of primary breast cancer (PBC) patients. We report that the majority of tumor-infiltrating CD4+ and CD8+ T cells have terminally exhaustive phenotype as assessed by CD39 and PD-1 expressions. We also show that Tregs are accumulated in breast TME compared to normal tissue. Further characterization of Tregs showed that these are mainly FoxP3+Helios+ and express high levels of CTLA-4 and PD-1. This preferential accumulation of FoxP3+Helios+ Treg subset with co-expression of different immune inhibitory molecules might have a negative effect on breast cancer prognosis. Taken together, our results suggest that breast tumor cells might utilize Tregs, and different suppressive pathways involving CD39, PD-1 and CTLA-4 molecules in creating an immune-subversive environment for them to survive, and a dual blockade of these immunosuppressive molecules might be considered as an effective method in breast cancer treatment.


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