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dc.contributor.authorBonifer, C
dc.contributor.authorLevantini, E
dc.contributor.authorKouskoff, Valerie
dc.contributor.authorLacaud, Georges
dc.date.accessioned2017-04-19T16:23:13Z
dc.date.available2017-04-19T16:23:13Z
dc.date.issued2017
dc.identifier.citationRunx1 structure and function in blood cell development. 2017, 962:65-81 Adv Exp Med Biolen
dc.identifier.issn0065-2598
dc.identifier.pmid28299651
dc.identifier.doi10.1007/978-981-10-3233-2_5
dc.identifier.urihttp://hdl.handle.net/10541/620249
dc.description.abstractRUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.
dc.language.isoenen
dc.rightsArchived with thanks to Advances in experimental medicine and biologyen
dc.titleRunx1 structure and function in blood cell development.en
dc.typeArticleen
dc.contributor.departmentInstitute for Cancer and Genomic Sciences, University of Birmingham, Birminghamen
dc.identifier.journalAdvances in Experimental Medicine and Biologyen
html.description.abstractRUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.


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