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    Runx1 structure and function in blood cell development.

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    Authors
    Bonifer, C
    Levantini, E
    Kouskoff, Valerie
    Lacaud, Georges
    Affiliation
    Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham
    Issue Date
    2017
    
    Metadata
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    Abstract
    RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.
    Citation
    Runx1 structure and function in blood cell development. 2017, 962:65-81 Adv Exp Med Biol
    Journal
    Advances in Experimental Medicine and Biology
    URI
    http://hdl.handle.net/10541/620249
    DOI
    10.1007/978-981-10-3233-2_5
    PubMed ID
    28299651
    Type
    Article
    Language
    en
    ISSN
    0065-2598
    ae974a485f413a2113503eed53cd6c53
    10.1007/978-981-10-3233-2_5
    Scopus Count
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    All Paterson Institute for Cancer Research

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