Affiliation
Institute for Cancer and Genomic Sciences, University of Birmingham, BirminghamIssue Date
2017
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Show full item recordAbstract
RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.Citation
Runx1 structure and function in blood cell development. 2017, 962:65-81 Adv Exp Med BiolJournal
Advances in Experimental Medicine and BiologyDOI
10.1007/978-981-10-3233-2_5PubMed ID
28299651Type
ArticleLanguage
enISSN
0065-2598ae974a485f413a2113503eed53cd6c53
10.1007/978-981-10-3233-2_5
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