AffiliationInstitute for Cancer and Genomic Sciences, University of Birmingham, Birmingham
MetadataShow full item record
AbstractRUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.
CitationRunx1 structure and function in blood cell development. 2017, 962:65-81 Adv Exp Med Biol
JournalAdvances in Experimental Medicine and Biology
- Transcriptional Auto-Regulation of RUNX1 P1 Promoter.
- Authors: Martinez M, Hinojosa M, Trombly D, Morin V, Stein J, Stein G, Javed A, Gutierrez SE
- Issue date: 2016
- Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.
- Authors: Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C
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- Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
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- Issue date: 2009 Jul 9
- RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.
- Authors: Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Soria NM, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, Bonifer C
- Issue date: 2017 May 23
- Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.
- Authors: Bras S, Martin-Lannerée S, Gobert V, Augé B, Breig O, Sanial M, Yamaguchi M, Haenlin M, Plessis A, Waltzer L
- Issue date: 2012 Mar 27