• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    CCR7+ selected gene-modified T ...
    Size:
    1.659Mb
    Format:
    PDF
    Description:
    full text open access article
    Download
    Authors
    Kueberuwa, Gray
    Gornall, Hannah
    Alcantar-Orozco, Erik M
    Bouvier, Deborah
    Kapacee, Zainul Abedin
    Hawkins, Robert E
    Gilham, David E
    Affiliation
    Clinical and Experimental Immunotherapy Group, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Division of Cancer Sciences, The University of Manchester, Wilmslow Road, Withington, Manchester
    Issue Date
    2017
    
    Metadata
    Show full item record
    Abstract
    Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. Efficient engraftment of T cells and persistence in the circulation correlate with favourable clinical outcomes. T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could therefore lead to improved clinical outcomes.
    Citation
    CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo. 2017, 5:14 J Immunother Cancer
    Journal
    Journal for Immunotherapy of Cancer
    URI
    http://hdl.handle.net/10541/620212
    DOI
    10.1186/s40425-017-0216-7
    PubMed ID
    28239467
    Type
    Article
    Language
    en
    ISSN
    2051-1426
    ae974a485f413a2113503eed53cd6c53
    10.1186/s40425-017-0216-7
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells.
    • Authors: Distler E, Bloetz A, Albrecht J, Asdufan S, Hohberger A, Frey M, Schnürer E, Thomas S, Theobald M, Hartwig UF, Herr W
    • Issue date: 2011 Jul
    • Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy.
    • Authors: Wu F, Zhang W, Shao H, Bo H, Shen H, Li J, Liu Y, Wang T, Ma W, Huang S
    • Issue date: 2013 Oct 10
    • Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation.
    • Authors: Hombach AA, Chmielewski M, Rappl G, Abken H
    • Issue date: 2013 Mar
    • A Correlation Between Differentiation Phenotypes of Infused T Cells and Anti-Cancer Immunotherapy.
    • Authors: Ren H, Cao K, Wang M
    • Issue date: 2021
    • The road to memory: an early rest for the long journey.
    • Authors: Ho LP, Yit PS, Ng LH, Linn YC, Zhao Y, Sun L, Ling KL, Chai Koh MB, Monica Shih MC, Li S, Wang XY, Tien SL, Goh YT
    • Issue date: 2013 Dec 1
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.