CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo.
Name:
CCR7+ selected gene-modified T ...
Size:
1.659Mb
Format:
PDF
Description:
full text open access article
Authors
Kueberuwa, GrayGornall, Hannah
Alcantar-Orozco, Erik M
Bouvier, Deborah
Kapacee, Zainul Abedin
Hawkins, Robert E
Gilham, David E
Affiliation
Clinical and Experimental Immunotherapy Group, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Division of Cancer Sciences, The University of Manchester, Wilmslow Road, Withington, ManchesterIssue Date
2017
Metadata
Show full item recordAbstract
Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. Efficient engraftment of T cells and persistence in the circulation correlate with favourable clinical outcomes. T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could therefore lead to improved clinical outcomes.Citation
CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo. 2017, 5:14 J Immunother CancerJournal
Journal for Immunotherapy of CancerDOI
10.1186/s40425-017-0216-7PubMed ID
28239467Type
ArticleLanguage
enISSN
2051-1426ae974a485f413a2113503eed53cd6c53
10.1186/s40425-017-0216-7
Scopus Count
Collections
Related articles
- Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells.
- Authors: Distler E, Bloetz A, Albrecht J, Asdufan S, Hohberger A, Frey M, Schnürer E, Thomas S, Theobald M, Hartwig UF, Herr W
- Issue date: 2011 Jul
- Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy.
- Authors: Wu F, Zhang W, Shao H, Bo H, Shen H, Li J, Liu Y, Wang T, Ma W, Huang S
- Issue date: 2013 Oct 10
- Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation.
- Authors: Hombach AA, Chmielewski M, Rappl G, Abken H
- Issue date: 2013 Mar
- A Correlation Between Differentiation Phenotypes of Infused T Cells and Anti-Cancer Immunotherapy.
- Authors: Ren H, Cao K, Wang M
- Issue date: 2021
- The road to memory: an early rest for the long journey.
- Authors: Ho LP, Yit PS, Ng LH, Linn YC, Zhao Y, Sun L, Ling KL, Chai Koh MB, Monica Shih MC, Li S, Wang XY, Tien SL, Goh YT
- Issue date: 2013 Dec 1