AffiliationDivision of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Wilmslow Road, Manchester, Wilmslow Road, Manchester, M20 4BX, UK
MetadataShow full item record
AbstractExcess body weight, commonly categorised as overweight (body mass index, BMI 25.0-29.9 kg/m(2)) and obesity (BMI ≥30 kg/m(2)) is an established risk factor for increased incidence of several adult cancers. As body weight is modifiable, there is a potential for cancer prevention. Calculation of attributable risk (here expressed at population attributable fraction, PAF) offers an estimate of the burden of excess cancers attributable to elevated BMI in populations, and thus an approximation of avoidable cases and the opportunity for prevention. Using counterfactual methods, the estimated PAF worldwide attributed to elevated BMI is 3.6 % or nearly half a million new cancer cases in adults (aged 30 years and older after a 10-year lag period). PAFs are higher in women compared with men (5.4 % vs. 1.9 %). Endometrial, post-menopausal breast, and colon cancers account for nearly two-thirds of cancers attributable to elevated BMI. Globally, excess body weight is the third commonest attributable risk factor for cancer (after smoking and infection); in western populations such as the UK, excess weight ranks as second commonest risk factor.
CitationObesity as an avoidable cause of cancer (attributable risks). 2016, 208:243-256 Recent Results Cancer Res
JournalRecent Results in Cancer Research
- Global burden of cancer attributable to high body-mass index in 2012: a population-based study.
- Authors: Arnold M, Pandeya N, Byrnes G, Renehan PAG, Stevens GA, Ezzati PM, Ferlay J, Miranda JJ, Romieu I, Dikshit R, Forman D, Soerjomataram I
- Issue date: 2015 Jan
- Cancers attributable to excess body weight in Canada in 2010.
- Authors: Zakaria D, Shaw A
- Issue date: 2017 Jul
- Proportion of Cancer Cases Attributable to Excess Body Weight by US State, 2011-2015.
- Authors: Islami F, Goding Sauer A, Gapstur SM, Jemal A
- Issue date: 2019 Mar 1
- Cancers in Australia in 2010 attributable to overweight and obesity.
- Authors: Kendall BJ, Wilson LF, Olsen CM, Webb PM, Neale RE, Bain CJ, Whiteman DC
- Issue date: 2015 Oct
- The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015.
- Authors: Brown KF, Rumgay H, Dunlop C, Ryan M, Quartly F, Cox A, Deas A, Elliss-Brookes L, Gavin A, Hounsome L, Huws D, Ormiston-Smith N, Shelton J, White C, Parkin DM
- Issue date: 2018 Apr