Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
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Authors
Hessmann, EPatzak, M S
Klein, L
Chen, N
Kari, V
Ramu, I
Bapiro, T E
Frese, Kristopher K
Gopinathan, A
Richards, F M
Jodrell, D I
Verbeke, C
Li, X
Heuchel, R
Löhr, J M
Johnsen, S A
Gress, T M
Ellenrieder, V
Neesse, A
Affiliation
Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, GermanyIssue Date
2017-01-10
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Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery.Citation
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. 2017, GutJournal
GutDOI
10.1136/gutjnl-2016-311954PubMed ID
28077438Type
ArticleLanguage
enISSN
1468-3288ae974a485f413a2113503eed53cd6c53
10.1136/gutjnl-2016-311954
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