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    Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.

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    Authors
    Hessmann, E
    Patzak, M S
    Klein, L
    Chen, N
    Kari, V
    Ramu, I
    Bapiro, T E
    Frese, Kristopher K
    Gopinathan, A
    Richards, F M
    Jodrell, D I
    Verbeke, C
    Li, X
    Heuchel, R
    Löhr, J M
    Johnsen, S A
    Gress, T M
    Ellenrieder, V
    Neesse, A
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    Affiliation
    Department Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen, Goettingen, Germany
    Issue Date
    2017-01-10
    
    Metadata
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    Abstract
    Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery.
    Citation
    Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. 2017, Gut
    Journal
    Gut
    URI
    http://hdl.handle.net/10541/620190
    DOI
    10.1136/gutjnl-2016-311954
    PubMed ID
    28077438
    Type
    Article
    Language
    en
    ISSN
    1468-3288
    ae974a485f413a2113503eed53cd6c53
    10.1136/gutjnl-2016-311954
    Scopus Count
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    All Paterson Institute for Cancer Research

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