• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Robust, universal biomarker assay to detect senescent cells in biological specimens.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Evangelou_et_al-2017-Aging_Cell.pdf
    Size:
    696.2Kb
    Format:
    PDF
    Description:
    Full text, Open Access Article
    Download
    Authors
    Evangelou, K
    Lougiakis, N
    Rizou, S
    Kotsinas, A
    Kletsas, D
    Muñoz-Espín, D
    Kastrinakis, N
    Pouli, N
    Marakos, P
    Townsend, Paul A
    Serrano, M
    Bartek, J
    Gorgoulis, Vassilis G
    Show allShow less
    Affiliation
    Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Issue Date
    2017-02
    
    Metadata
    Show full item record
    Abstract
    Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology.
    Citation
    Robust, universal biomarker assay to detect senescent cells in biological specimens. 2017, 16(1):192-197 Aging Cell
    Journal
    Aging Cell
    URI
    http://hdl.handle.net/10541/620182
    DOI
    10.1111/acel.12545
    PubMed ID
    28165661
    Type
    Article
    Language
    en
    ISSN
    1474-9726
    ae974a485f413a2113503eed53cd6c53
    10.1111/acel.12545
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Detecting senescence: a new method for an old pigment.
    • Authors: Salmonowicz H, Passos JF
    • Issue date: 2017 Jun
    • Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.
    • Authors: Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez Marcos PJ, Zoumpourlis V, Trougakos IP, Kletsas D, Bartek J, Serrano M, Gorgoulis VG
    • Issue date: 2013 Jan
    • Sudan Black B, The Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent Cells.
    • Authors: Evangelou K, Gorgoulis VG
    • Issue date: 2017
    • A Multiparametric Assay to Evaluate Senescent Cells.
    • Authors: Gal H, Porat Z, Krizhanovsky V
    • Issue date: 2019
    • A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.
    • Authors: Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG
    • Issue date: 2019
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.