• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The rationale for post-operative radiation in localized bladder cancer.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    blc%2F2017%2F3-1%2Fblc-3-1-blc ...
    Size:
    215.9Kb
    Format:
    PDF
    Description:
    Full text, Open Access Article
    Download
    Authors
    Baumann, B
    Sargos, P
    Eapen, L
    Efstathiou, J
    Choudhury, Ananya
    Bahl, A
    Murthy, V
    Ballas, L
    Fonteyne, V
    Richaud, P
    Zaghloul, M
    Christodouleas, J
    Show allShow less
    Affiliation
    Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Issue Date
    2017-01-27
    
    Metadata
    Show full item record
    Abstract
    Local-regional recurrence for patients with ≥pT3 disease after radical cystectomy is a significant problem. Chemotherapy has not been shown to reduce the risk of local-regional recurrences in randomized prospective trials, and salvage therapies for local-regional failure are rarely successful. There is promising evidence, particularly from a recent Egyptian NCI trial, that radiation therapy plus chemotherapy can significantly reduce local recurrences compared to chemotherapy alone, and that this improvement in local-regional control may translate to meaningful improvements in disease-free and overall survival with acceptable toxicity. In light of the high rates of local failure following cystectomy for locally advanced disease and the progress that has been made in identifying patients at high risk of failure and the patterns of failure in the pelvis, the NCCN guidelines were revised in 2016 to include post-operative radiotherapy as an option to consider for patients with ≥pT3 disease. Despite advances in our understanding of the problem of local-regional failure after cystectomy and the potential role of adjuvant radiotherapy, the question of whether adjuvant radiotherapy should have a defined role for patients with locally advanced urothelial carcinoma has not yet been determined. The results of the NRG, European, Indian, and Egyptian trials on adjuvant radiotherapy are eagerly awaited. While none of these trials on their own may provide definitive conclusions, their aggregate outcomes will help clarify whether this treatment should have a role in the management of patients with locally advanced bladder cancer.
    Citation
    The rationale for post-operative radiation in localized bladder cancer. 2017, 3(1):19-30 Bladder Cancer
    Journal
    Bladder Cancer
    URI
    http://hdl.handle.net/10541/620168
    DOI
    10.3233/BLC-160081
    PubMed ID
    28149931
    Type
    Article
    Language
    en
    ISSN
    2352-3727
    ae974a485f413a2113503eed53cd6c53
    10.3233/BLC-160081
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Adjuvant and Neoadjuvant Radiation Therapy for Locally Advanced Bladder Cancer.
    • Authors: Baumann BC, Zaghloul MS, Sargos P, Murthy V
    • Issue date: 2021 Jun
    • A novel risk stratification to predict local-regional failures in urothelial carcinoma of the bladder after radical cystectomy.
    • Authors: Baumann BC, Guzzo TJ, He J, Keefe SM, Tucker K, Bekelman JE, Hwang WT, Vaughn DJ, Malkowicz SB, Christodouleas JP
    • Issue date: 2013 Jan 1
    • Bladder cancer patterns of pelvic failure: implications for adjuvant radiation therapy.
    • Authors: Baumann BC, Guzzo TJ, He J, Vaughn DJ, Keefe SM, Vapiwala N, Deville C, Bekelman JE, Tucker K, Hwang WT, Malkowicz SB, Christodouleas JP
    • Issue date: 2013 Feb 1
    • Adjuvant Radiotherapy Use by US Radiation Oncologists After Radical Cystectomy for Muscle-invasive Bladder Cancer.
    • Authors: Solanki AA, Martin B, Korpics M, Small C, Harkenrider MM, Mitin T
    • Issue date: 2017 Jul
    • Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer - study protocol of a prospective, single arm, multicenter phase II trial (RACE IT).
    • Authors: Schmid SC, Koll FJ, Rödel C, Maisch P, Sauter A, Beckert F, Seitz A, Kübler H, Flentje M, Chun F, Combs SE, Schiller K, Gschwend JE, Retz M
    • Issue date: 2020 Jan 3
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.