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    Of hemangioblast, hemogenic endothelium and primitive versus definitive hematopoiesis.

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    Authors
    Lacaud, Georges
    Kouskoff, Valerie
    Affiliation
    Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow road
    Issue Date
    2016-12-30
    
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    Abstract
    The types of progenitors generated during the successive stages of embryonic blood development are now fairly well characterized. The terminology used to describe these waves, however, can still be confusing. What is truly primitive? What is uniquely definitive? These questions become even more challenging to answer when blood progenitors are derived in vitro upon the differentiation of embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs). Similarly, the cellular origin of these blood progenitors can be controversial. Are all blood cells, including the primitive wave, derived from hemogenic endothelium? Is the hemangioblast an in vitro artefact or is this mesoderm entity also present in the developing embryo? Here we discuss the latest findings and propose some consensus relating to these controversial issues.
    Citation
    Of hemangioblast, hemogenic endothelium and primitive versus definitive hematopoiesis. 2016 Exp Hematol
    Journal
    Experimental Hematology
    URI
    http://hdl.handle.net/10541/620144
    DOI
    10.1016/j.exphem.2016.12.009
    PubMed ID
    28043822
    Type
    Article
    Language
    en
    ISSN
    1873-2399
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.exphem.2016.12.009
    Scopus Count
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