Of hemangioblast, hemogenic endothelium and primitive versus definitive hematopoiesis.
Affiliation
Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow roadIssue Date
2016-12-30
Metadata
Show full item recordAbstract
The types of progenitors generated during the successive stages of embryonic blood development are now fairly well characterized. The terminology used to describe these waves, however, can still be confusing. What is truly primitive? What is uniquely definitive? These questions become even more challenging to answer when blood progenitors are derived in vitro upon the differentiation of embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs). Similarly, the cellular origin of these blood progenitors can be controversial. Are all blood cells, including the primitive wave, derived from hemogenic endothelium? Is the hemangioblast an in vitro artefact or is this mesoderm entity also present in the developing embryo? Here we discuss the latest findings and propose some consensus relating to these controversial issues.Citation
Of hemangioblast, hemogenic endothelium and primitive versus definitive hematopoiesis. 2016 Exp HematolJournal
Experimental HematologyDOI
10.1016/j.exphem.2016.12.009PubMed ID
28043822Type
ArticleLanguage
enISSN
1873-2399ae974a485f413a2113503eed53cd6c53
10.1016/j.exphem.2016.12.009