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    Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

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    Authors
    Dobrolecki, L
    Airhart, S
    Alférez, Denis G
    Aparicio, S
    Behbod, F
    Bentires-Alj, M
    Brisken, C
    Bult, C
    Cai, S
    Clarke, R
    Dowst, H
    Ellis, M
    Gonzalez-Suarez, E
    Iggo, R
    Kabos, P
    Li, S
    Lindeman, G
    Marangoni, E
    McCoy, A
    Meric-Bernstam, F
    Piwnica-Worms, H
    Poupon, M
    Reis-Filho, J
    Sartorius, C
    Scabia, V
    Sflomos, G
    Tu, Y
    Vaillant, F
    Visvader, J
    Welm, A
    Wicha, M
    Lewis, M
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    Affiliation
    The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston, TX, 77030
    Issue Date
    2016-12
    
    Metadata
    Show full item record
    Abstract
    Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.
    Citation
    Patient-derived xenograft (PDX) models in basic and translational breast cancer research. 2016, 35 (4):547-573 Cancer Metastasis Rev
    Journal
    Cancer Metastasis Reviews
    URI
    http://hdl.handle.net/10541/620142
    DOI
    10.1007/s10555-016-9653-x
    PubMed ID
    28025748
    Additional Links
    http://link.springer.com/article/10.1007%2Fs10555-016-9653-x
    Type
    Article
    Language
    en
    ISSN
    1573-7233
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10555-016-9653-x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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