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dc.contributor.authorLamarca, Angelaen
dc.contributor.authorBarriuso, Jorgeen
dc.contributor.authorMcNamara, Mairéad Gen
dc.contributor.authorHubner, Richard Aen
dc.contributor.authorValle, Juan Wen
dc.date.accessioned2017-01-30T15:42:52Z
dc.date.available2017-01-30T15:42:52Z
dc.date.issued2016-12
dc.identifier.citationTelotristat ethyl: a new option for the management of carcinoid syndrome. 2016, 17 (18):2487-2498 Expert Opin Pharmacotheren
dc.identifier.issn1744-7666
dc.identifier.pmid27817224
dc.identifier.doi10.1080/14656566.2016.1254191
dc.identifier.urihttp://hdl.handle.net/10541/620099
dc.description.abstractMany patients with neuroendocrine tumour-related carcinoid syndrome treated with somatostatin analogues (SSA) won't achieve adequate symptom relief with the SSA alone; new treatment options are required. Telotristat ethyl is a tryptophan hydroxylase inhibitor, developed for the treatment of carcinoid syndrome. Areas covered: This review summarises the evidence supporting the role of telotristat ethyl in the management of carcinoid syndrome. Rationale, pharmacodynamics, pharmacokinetics, metabolism, clinical experience, efficacy and toxicity profiles are covered. Expert opinion: The efficacy of telotristat ethyl in producing a statistically-significant and clinically-meaningful reduction in daily bowel movements has been confirmed in phase III clinical trials. Two pivotal trials, TELESTAR and TELECAST, explored the role of telotristat ethyl in the management of patients with carcinoid syndrome refractory to SSAs focusing on patients with ≥4 and <4 daily bowel movements, respectively. In addition, benefit was confirmed in patient-reported outcomes. Based on activity and safe toxicity profile, telotristat ethyl is pending regulatory agencies evaluation and is likely to add to the armamentarium used to treat carcinoid syndrome. Long-term safety and efficacy data will be available from the ongoing TELEPATH study. The impact on carcinoid heart disease, mesenteric fibrosis and other long-term complications of carcinoid syndrome as well as its role earlier in patients' pathways remain investigational.
dc.language.isoenen
dc.rightsArchived with thanks to Expert opinion on pharmacotherapyen
dc.titleTelotristat ethyl: a new option for the management of carcinoid syndrome.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology , The Christie NHS Foundation Trust , Manchesteren
dc.identifier.journalExpert Opinion on Pharmacotherapyen
html.description.abstractMany patients with neuroendocrine tumour-related carcinoid syndrome treated with somatostatin analogues (SSA) won't achieve adequate symptom relief with the SSA alone; new treatment options are required. Telotristat ethyl is a tryptophan hydroxylase inhibitor, developed for the treatment of carcinoid syndrome. Areas covered: This review summarises the evidence supporting the role of telotristat ethyl in the management of carcinoid syndrome. Rationale, pharmacodynamics, pharmacokinetics, metabolism, clinical experience, efficacy and toxicity profiles are covered. Expert opinion: The efficacy of telotristat ethyl in producing a statistically-significant and clinically-meaningful reduction in daily bowel movements has been confirmed in phase III clinical trials. Two pivotal trials, TELESTAR and TELECAST, explored the role of telotristat ethyl in the management of patients with carcinoid syndrome refractory to SSAs focusing on patients with ≥4 and <4 daily bowel movements, respectively. In addition, benefit was confirmed in patient-reported outcomes. Based on activity and safe toxicity profile, telotristat ethyl is pending regulatory agencies evaluation and is likely to add to the armamentarium used to treat carcinoid syndrome. Long-term safety and efficacy data will be available from the ongoing TELEPATH study. The impact on carcinoid heart disease, mesenteric fibrosis and other long-term complications of carcinoid syndrome as well as its role earlier in patients' pathways remain investigational.


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