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    Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.

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    Authors
    Valassi, E
    Crespo, I
    Keevil, B
    Aulinas, A
    Urgell, E
    Santos, A
    Trainer, Peter J
    Webb, S
    Affiliation
    Endocrinology/Medicine DepartmentHospital Sant Pau, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autonoma de Barcelona (UAB), Barcelona
    Issue Date
    2017-02
    
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    Abstract
    Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations.
    Citation
    Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels. 2017, 176 (2):221-231 Eur J Endocrinol
    Journal
    European Journal of Endocrinology
    URI
    http://hdl.handle.net/10541/620078
    DOI
    10.1530/EJE-16-0779
    PubMed ID
    27932530
    Type
    Article
    Language
    en
    ISSN
    1479-683X
    ae974a485f413a2113503eed53cd6c53
    10.1530/EJE-16-0779
    Scopus Count
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