Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.
AffiliationEndocrinology/Medicine DepartmentHospital Sant Pau, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autonoma de Barcelona (UAB), Barcelona
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AbstractAffective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations.
CitationAffective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels. 2017, 176 (2):221-231 Eur J Endocrinol
JournalEuropean Journal of Endocrinology