High-grade neuroendocrine carcinoma of the lung with carcinoid morphology: a study of 12 cases.
AffiliationDepartment of Histopathology, The University Hospital of South Manchester NHS Foundation Trust
MetadataShow full item record
AbstractTwelve lung neuroendocrine tumors with morphologic features of carcinoid tumors but with mitotic count >10/2 mm are reported. There were 7 males and 5 females, with age ranging from 56 to 78 years. Four cases were from never-smokers. All tumors showed architectural and cytomorphologic features of carcinoid tumor, including organoid nesting, insular, trabecular, or acinar growth, and tumor cells with low nucleocytoplasmic ratio, abundant cytoplasm, ovoid to round nuclei, and salt and pepper chromatin. Angulated or confluent nesting, insular or lobular growth pattern was also seen. Nuclear irregularities and anisonucleosis were focally present. Mitotic count ranged from 11 to 61/2 mm. Punctate-type necrosis was present in 8 tumors. Anaplastic cytology, large infarct-type necrosis, desmoplasia, or marked inflammatory infiltrate was not found in any of the tumors. One tumor occurred in the background of diffuse idiopathic pulmonary neuroendocrine hyperplasia. All tumors were treated by resection, and all but 1 patient subsequently developed metastasis, and 7 died of the tumor. For metastatic tumors, 4 patients were treated by platinum-based chemotherapy with no apparent response, whereas 3 other patients were treated by combined capecitabine and temozolomide-novel chemotherapy for well-differentiated neuroendocrine tumor/carcinoid tumor-2 of them responded. This subset of tumor would be classified as large cell neuroendocrine carcinoma according to the current WHO classification scheme, but their clinical and pathologic features appear to have more in common with the carcinoid tumor group than large cell neuroendocrine carcinoma, therefore, identification of this subset may be relevant for further therapeutic management.
CitationHigh-grade neuroendocrine carcinoma of the lung with carcinoid morphology: a study of 12 cases. 2016: Am. J. Surg. Pathol.
JournalThe American Journal of Surgical Pathology
- [Pulmonary neuroendocrine tumors. The spectrum of histologic subtypes and current concept on diagnosis and treatment].
- Authors: Langfort R, Rudziński P, Burakowska B
- Issue date: 2010
- Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases.
- Authors: Gilks CB, Young RH, Gersell DJ, Clement PB
- Issue date: 1997 Aug
- Pulmonary carcinoid and related tumours.
- Authors: Hasleton PS, Bostanci G
- Issue date: 1997
- Ovarian mucinous carcinoids including some with a carcinomatous component: a report of 17 cases.
- Authors: Baker PM, Oliva E, Young RH, Talerman A, Scully RE
- Issue date: 2001 May
- Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung.
- Authors: Tsuta K, Raso MG, Kalhor N, Liu DD, Wistuba II, Moran CA
- Issue date: 2011 Jan