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    Imaging biomarker roadmap for cancer studies.

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    nrclinonc.2016.162.pdf
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    Authors
    O'Connor, James P B
    Aboagye, E
    Adams, J
    Aerts, H
    Barrington, S
    Beer, A
    Boellaard, R
    Bohndiek, S
    Brady, M
    Brown, G
    Buckley, D
    Chenevert, T
    Clarke, L
    Collette, S
    Cook, G
    deSouza, N
    Dickson, J
    Dive, Caroline
    Evelhoch, J
    Faivre-Finn, Corinne
    Gallagher, F
    Gilbert, F
    Gillies, R
    Goh, V
    Griffiths, J
    Groves, A
    Halligan, S
    Harris, A
    Hawkes, D
    Hoekstra, O
    Huang, E
    Hutton, B
    Jackson, E
    Jayson, Gordon C
    Jones, A
    Koh, D
    Lacombe, D
    Lambin, P
    Lassau, N
    Leach, M
    Lee, T
    Leen, E
    Lewis, J
    Liu, Y
    Lythgoe, M
    Manoharan, Prakash
    Maxwell, R
    Miles, K
    Morgan, B
    Morris, S
    Ng, T
    Padhani, A
    Parker, Geoff J M
    Partridge, M
    Pathak, A
    Peet, A
    Punwani, S
    Reynolds, A
    Robinson, S
    Shankar, L
    Sharma, R
    Soloviev, D
    Stroobants, S
    Sullivan, D
    Taylor, St
    Tofts, P
    Tozer, G
    van Herk, Marcel
    Walker-Samuel, S
    Wason, J
    Williams, Kaye J
    Workman, P
    Yankeelov, T
    Brindle, K
    McShane, L
    Jackson, Alan
    Waterton, John C
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    Affiliation
    CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK
    Issue Date
    2016-10-11
    
    Metadata
    Show full item record
    Abstract
    Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored 'roadmap'. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use.
    Citation
    Imaging biomarker roadmap for cancer studies. 2016, Nat Rev Clin Oncol
    Journal
    Nature Reviews. Clinical Oncology
    URI
    http://hdl.handle.net/10541/620035
    DOI
    10.1038/nrclinonc.2016.162
    PubMed ID
    27725679
    Type
    Article
    Language
    en
    ISSN
    1759-4782
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrclinonc.2016.162
    Scopus Count
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