IncucyteDRC: An R package for the dose response analysis of live cell imaging data.
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Authors
Chapman, Philip JJames, Dominic I
Watson, Amanda J
Hopkins, Gemma V
Waddell, Ian D
Ogilvie, Donald J
Affiliation
Drug Discovery Unit, Cancer Research UK Manchester Institute, Manchester, UKIssue Date
2016
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We present IncucyteDRC, an R package for the analysis of data from live cell imaging cell proliferation experiments carried out on the Essen Biosciences IncuCyte ZOOM instrument. The package provides a simple workflow for summarising data into a form that can be used to calculate dose response curves and EC50 values for small molecule inhibitors. Data from different cell lines, or cell lines grown under different conditions, can be normalised as to their doubling time. A simple graphical web interface, implemented using shiny, is provided for the benefit of non-R users. The software is potentially useful to any research group studying the impact of small molecule inhibitors on cell proliferation using the IncuCyte ZOOM.Citation
IncucyteDRC: An R package for the dose response analysis of live cell imaging data. 2016, 5:962 F1000ResJournal
F1000ResearchDOI
10.12688/f1000research.8694.1PubMed ID
27703665Type
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enae974a485f413a2113503eed53cd6c53
10.12688/f1000research.8694.1
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