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    IncucyteDRC: An R package for the dose response analysis of live cell imaging data.

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    Authors
    Chapman, Philip J
    James, Dominic I
    Watson, Amanda J
    Hopkins, Gemma V
    Waddell, Ian D
    Ogilvie, Donald J
    Affiliation
    Drug Discovery Unit, Cancer Research UK Manchester Institute, Manchester, UK
    Issue Date
    2016
    
    Metadata
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    Abstract
    We present IncucyteDRC, an R package for the analysis of data from live cell imaging cell proliferation experiments carried out on the Essen Biosciences IncuCyte ZOOM instrument. The package provides a simple workflow for summarising data into a form that can be used to calculate dose response curves and EC50 values for small molecule inhibitors. Data from different cell lines, or cell lines grown under different conditions, can be normalised as to their doubling time. A simple graphical web interface, implemented using shiny, is provided for the benefit of non-R users. The software is potentially useful to any research group studying the impact of small molecule inhibitors on cell proliferation using the IncuCyte ZOOM.
    Citation
    IncucyteDRC: An R package for the dose response analysis of live cell imaging data. 2016, 5:962 F1000Res
    Journal
    F1000Research
    URI
    http://hdl.handle.net/10541/620016
    DOI
    10.12688/f1000research.8694.1
    PubMed ID
    27703665
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.12688/f1000research.8694.1
    Scopus Count
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    All Paterson Institute for Cancer Research

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