HPV-related oropharyngeal cancer in the United Kingdom: an evolution in understanding of disease etiology.
West, Catharine M L
Oguejiofor, Kenneth K
AffiliationMolecular & Clinical Cancer Medicine, University of Liverpool
MetadataShow full item record
AbstractA rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter cross-sectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative OPSCC within the United Kingdom (UK). Archival tumor tissue blocks from 1602 patients previously diagnosed with OPSCC (2002-2011) were collated from 11 centers. HPV status was determined with 3 validated commercial tests to provide valid data for 1474 cases in total. Corresponding national incidence data from the same decade were obtained from UK Cancer registries.The overall proportion of HPV+ OPSCC between 2002-2011 was 51.8% (95% CI:49.3, 54.4) and this remained unchanged throughout the decade (unadjusted risk ratio:1.00 (95% CI:0.99, 1.02). However, over the same period, the incidence of OPSCC in the broader UK population underwent a 2-fold increase (age standardised rate (ASR) 2002:2.1 (95% CI:1.9, 2.2); 2011:4.1(95% CI:4.0, 4.3)). Although the number of OPSCC diagnosed within the UK from 2002-2011 nearly doubled, the proportion of HPV+ cases remained static at ~50%. Our results argue that the rapidly increasing incidence of OPSCC in the UK cannot be solely attributable to the influence of HPV. The parallel increase in HPV+ and HPV- cases we documented warrants further investigation, so that appropriate future prevention strategies for both types of disease can be implemented.
CitationHPV-related oropharyngeal cancer in the United Kingdom: an evolution in understanding of disease etiology. 2016, Cancer Res
- Incidence of Oropharyngeal Cancer Among Elderly Patients in the United States.
- Authors: Zumsteg ZS, Cook-Wiens G, Yoshida E, Shiao SL, Lee NY, Mita A, Jeon C, Goodman MT, Ho AS
- Issue date: 2016 Dec 1
- Human papillomavirus and oropharyngeal cancer in Greenland in 1994-2010.
- Authors: Avnstorp MB, Jensen RG, Garnæs E, Therkildsen MH, Norrild B, Specht L, von Buchwald C, Homøe P
- Issue date: 2013
- HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation.
- Authors: van Kempen PM, van Bockel L, Braunius WW, Moelans CB, van Olst M, de Jong R, Stegeman I, van Diest PJ, Grolman W, Willems SM
- Issue date: 2014 Oct
- Prognostic implications of human papillomavirus status for patients with non-oropharyngeal head and neck squamous cell carcinomas.
- Authors: Ko HC, Harari PM, Sacotte RM, Chen S, Wieland AM, Yu M, Baschnagel AM, Bruce JY, Kimple RJ, Witek ME
- Issue date: 2017 Nov
- Incidence Changes of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma and Effects on Survival in the Netherlands Cancer Institute, 1980-2009.
- Authors: Henneman R, Van Monsjou HS, Verhagen CV, Van Velthuysen ML, Ter Haar NT, Osse EM, Lopez-Yurda MI, Balm AJ, Van Den Brekel MW
- Issue date: 2015 Jul