A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours.
Authors
Jamieson, DGriffin, M
Sludden, J
Drew, Y
Cresti, N
Swales, K
Merriman, M
Allen, R
Bevan, P
Buerkle, M
Mala, C
Coyle, V
Rodgers, L
Dean, Emma J
Greystoke, A
Banerji, U
Wilson, R
Evans, T
Anthoney, A
Ranson, Malcolm R
Boddy, A
Plummer, R
Affiliation
Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH,Issue Date
2016-09-28
Metadata
Show full item recordAbstract
We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determine the optimal biological dose for subsequent trials.Citation
A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours. 2016, 68:1-10 Eur. J. CancerJournal
European Journal of CancerDOI
10.1016/j.ejca.2016.08.026PubMed ID
27693888Type
ArticleLanguage
enISSN
1879-0852ae974a485f413a2113503eed53cd6c53
10.1016/j.ejca.2016.08.026
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