Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer.
Affiliation
Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, ManchesterIssue Date
2016-09
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Despite better understanding of it's molecular biology, non-small cell lung cancer (NSCLC) remains a challenging disease to treat. Unfortunately, treatment options are still very limited and prognosis for advanced disease is poor. Immune surveillance plays a crucial role in a host's defence against tumour cells, and this is particular relevant for lung cancer due to it's high somatic mutational load, which increases the chances for the immune system to recognize cancer cells as 'non-self'. Novel immunotherapies are emerging as an effective treatment for this disease. In this review, we present the data on immune checkpoint inhibitors for NSCLC, describing their mechanism of action, data efficacy from recent clinical trials, and strategies to select patients more likely to benefit from these agents.Citation
Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer. 2016, 18 (9):59 Curr Oncol RepJournal
Current Oncology ReportsDOI
10.1007/s11912-016-0544-7PubMed ID
27484062Type
ArticleLanguage
enISSN
1534-6269ae974a485f413a2113503eed53cd6c53
10.1007/s11912-016-0544-7
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