Show simple item record

dc.contributor.authorLilly, Andrew J
dc.contributor.authorLacaud, Georges
dc.contributor.authorKouskoff, Valerie
dc.date.accessioned2016-10-05T10:32:13Z
dc.date.available2016-10-05T10:32:13Z
dc.date.issued2016-07-25
dc.identifier.citationSOXF transcription factors in cardiovascular development. 2016: Semin. Cell Dev. Biol.en
dc.identifier.issn1096-3634
dc.identifier.pmid27470491
dc.identifier.doi10.1016/j.semcdb.2016.07.021
dc.identifier.urihttp://hdl.handle.net/10541/619928
dc.description.abstractCardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to Seminars in cell & developmental biologyen
dc.titleSOXF transcription factors in cardiovascular development.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK, Stem Cell Hematopoiesis, The University of Manchester, Wilmslow road, M20 4BXen
dc.identifier.journalSeminars in Cell & Developmental Biologyen
html.description.abstractCardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.


Files in this item

This item appears in the following Collection(s)

Show simple item record