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    SOXF transcription factors in cardiovascular development.

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    Authors
    Lilly, Andrew J
    Lacaud, Georges
    Kouskoff, Valerie
    Affiliation
    Cancer Research UK, Stem Cell Hematopoiesis, The University of Manchester, Wilmslow road, M20 4BX
    Issue Date
    2016-07-25
    
    Metadata
    Show full item record
    Abstract
    Cardiovascular development during embryogenesis involves complex changes in gene regulatory networks regulated by a variety of transcription factors. In this review we discuss the various reported roles of the SOXF factors: SOX7, SOX17 and SOX18 in cardiac, vascular and lymphatic development. SOXF factors have pleiotropic roles during these processes, and there is significant redundancy and functional compensation between SOXF family members. Despite this, evidence suggests that there is some specificity in the transcriptional programs they regulate which is necessary to control the differentiation and behaviour of endothelial subpopulations. Furthermore, SOXF factors appear to have an indirect role in regulating cardiac mesoderm specification and differentiation. Understanding how SOXF factors are regulated, as well as their downstream transcriptional target genes, will be important for unravelling their roles in cardiovascular development and related diseases.
    Citation
    SOXF transcription factors in cardiovascular development. 2016: Semin. Cell Dev. Biol.
    Journal
    Seminars in Cell & Developmental Biology
    URI
    http://hdl.handle.net/10541/619928
    DOI
    10.1016/j.semcdb.2016.07.021
    PubMed ID
    27470491
    Type
    Article
    Language
    en
    ISSN
    1096-3634
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.semcdb.2016.07.021
    Scopus Count
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    All Paterson Institute for Cancer Research

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