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    Reducing prostaglandin E2 production to raise cancer immunogenicity.

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    Authors
    Zelenay, Santiago
    Reis E Sousa, C
    Affiliation
    Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester
    Issue Date
    2016-05
    
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    Abstract
    Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.
    Citation
    Reducing prostaglandin E2 production to raise cancer immunogenicity. 2016, 5 (5):e1123370 Oncoimmunology
    Journal
    Oncoimmunology
    URI
    http://hdl.handle.net/10541/619926
    DOI
    10.1080/2162402X.2015.1123370
    PubMed ID
    27467936
    Type
    Article
    Language
    en
    ISSN
    2162-4011
    ae974a485f413a2113503eed53cd6c53
    10.1080/2162402X.2015.1123370
    Scopus Count
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    All Paterson Institute for Cancer Research

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