Reducing prostaglandin E2 production to raise cancer immunogenicity.
AffiliationCancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester
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AbstractCyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.
CitationReducing prostaglandin E2 production to raise cancer immunogenicity. 2016, 5 (5):e1123370 Oncoimmunology