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dc.contributor.authorFreeman, Karoline
dc.contributor.authorSaunders, Mark P
dc.contributor.authorUthman, Olalekan A
dc.contributor.authorTaylor-Phillips, Sian
dc.contributor.authorConnock, Martin
dc.contributor.authorCourt, Rachel
dc.contributor.authorGurung, Tara
dc.contributor.authorSutcliffe, Paul
dc.contributor.authorClarke, Aileen
dc.date.accessioned2016-10-04T13:25:56Z
dc.date.available2016-10-04T13:25:56Z
dc.date.issued2016
dc.identifier.citationIs monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review. 2016, 16:523 BMC Canceren
dc.identifier.issn1471-2407
dc.identifier.pmid27456697
dc.identifier.doi10.1186/s12885-016-2581-x
dc.identifier.urihttp://hdl.handle.net/10541/619917
dc.description.abstractPharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liquid chromatography and a high throughput nanoparticle immunoassay (My5-FU) have been used in conjunction with treatment algorithms to guide dosing. The objective of this study was to assess accuracy, clinical effectiveness and safety of plasma 5-fluorouracil guided dose regimen(s) versus standard regimens based on body surface area in colorectal cancer.
dc.language.isoenen
dc.rightsArchived with thanks to BMC canceren
dc.titleIs monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review.en
dc.typeArticleen
dc.contributor.departmentDivision of Health Sciences, Medical School, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UKen
dc.identifier.journalBMC Canceren
refterms.dateFOA2018-12-17T14:39:21Z
html.description.abstractPharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liquid chromatography and a high throughput nanoparticle immunoassay (My5-FU) have been used in conjunction with treatment algorithms to guide dosing. The objective of this study was to assess accuracy, clinical effectiveness and safety of plasma 5-fluorouracil guided dose regimen(s) versus standard regimens based on body surface area in colorectal cancer.


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