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    Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review.

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    Authors
    Freeman, Karoline
    Saunders, Mark P
    Uthman, Olalekan A
    Taylor-Phillips, Sian
    Connock, Martin
    Court, Rachel
    Gurung, Tara
    Sutcliffe, Paul
    Clarke, Aileen
    Affiliation
    Division of Health Sciences, Medical School, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK
    Issue Date
    2016
    
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    Abstract
    Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liquid chromatography and a high throughput nanoparticle immunoassay (My5-FU) have been used in conjunction with treatment algorithms to guide dosing. The objective of this study was to assess accuracy, clinical effectiveness and safety of plasma 5-fluorouracil guided dose regimen(s) versus standard regimens based on body surface area in colorectal cancer.
    Citation
    Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review. 2016, 16:523 BMC Cancer
    Journal
    BMC Cancer
    URI
    http://hdl.handle.net/10541/619917
    DOI
    10.1186/s12885-016-2581-x
    PubMed ID
    27456697
    Type
    Article
    Language
    en
    ISSN
    1471-2407
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12885-016-2581-x
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