Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy.
| dc.contributor.author | Iavazzo, Christos | |
| dc.contributor.author | Gkegkes, I | |
| dc.contributor.author | Vrachnis, N | |
| dc.date.accessioned | 2016-09-06T09:47:22Z | |
| dc.date.available | 2016-09-06T09:47:22Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy. 2016, 17 (2):73-6 J Turk Ger Gynecol Assoc | en |
| dc.identifier.issn | 1309-0399 | |
| dc.identifier.pmid | 27403072 | |
| dc.identifier.doi | 10.5152/jtgga.2016.15223 | |
| dc.identifier.uri | http://hdl.handle.net/10541/619877 | |
| dc.description.abstract | The presence of deleterious mutations in breast cancer (BRCA)-1 or BRCA-2 gene has a decisive influence on the development of various types of neoplasms, such as breast, ovarian, tubal, and peritoneal cancers. Primary peritoneal cancer is an aggressive malignancy which, due to the absence of a specific screening test, cannot be diagnosed in its early stages. As a risk-reducing option, prophylactic bilateral salpingo-oophorectomy and mastectomy are often proposed in BRCA gene carriers. The effectiveness of a preventive surgical treatment is, however, unclear in the development of peritoneal cancer. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Journal of the Turkish German Gynecological Association | en |
| dc.title | Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy. | en |
| dc.type | Article | en |
| dc.contributor.department | Gynaecological Oncology Department, Christie Hospital, Manchester | en |
| dc.identifier.journal | Journal of the Turkish German Gynecological Association | en |
| html.description.abstract | The presence of deleterious mutations in breast cancer (BRCA)-1 or BRCA-2 gene has a decisive influence on the development of various types of neoplasms, such as breast, ovarian, tubal, and peritoneal cancers. Primary peritoneal cancer is an aggressive malignancy which, due to the absence of a specific screening test, cannot be diagnosed in its early stages. As a risk-reducing option, prophylactic bilateral salpingo-oophorectomy and mastectomy are often proposed in BRCA gene carriers. The effectiveness of a preventive surgical treatment is, however, unclear in the development of peritoneal cancer. |