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    Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.

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    Authors
    Marei, Hadir
    Malliri, Angeliki
    Affiliation
    Cell Signaling Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester M20 4BX
    Issue Date
    2016-07-21
    
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    Abstract
    Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including, cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 represents an attractive therapeutic target, yet the search for effective Rac1 inhibitors is still underway. Given the adverse effects associated with Rac1 signaling perturbation, cells have evolved several mechanisms to ensure the tight regulation of Rac1 signaling. Thus, characterizing these mechanisms can provide invaluable information regarding major cellular events that lead to aberrant Rac1 signaling. Importantly, this information can be utilized to further facilitate the development of effective pharmacological modulators that can restore normal Rac1 signaling. In this review, we focus on the pathological role of Rac1 signaling, highlighting the benefits and potential drawbacks of targeting Rac1 in a clinical setting. Additionally, we provide an overview of available compounds that target key Rac1 regulatory mechanisms and discuss future therapeutic avenues arising from our understanding of these mechanisms.
    Citation
    Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms. 2016, (0) Small GTPases
    Journal
    Small GTPases
    URI
    http://hdl.handle.net/10541/618471
    DOI
    10.1080/21541248.2016.1211398
    PubMed ID
    27442895
    Type
    Article
    Language
    en
    ISSN
    2154-1256
    ae974a485f413a2113503eed53cd6c53
    10.1080/21541248.2016.1211398
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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