Intractable hypoglycaemia in a patient with advanced carcinoid syndrome successfully treated with hepatic embolization.
Affiliation
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre; Manchester; UKIssue Date
2015-01
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A male patient presented at the age of 54 years with metastatic pancreatic neuroendocrine tumour (NET). He was managed with interferon and multiple courses of MIBG therapy which controlled his disease for about seven years. He then developed symptomatic hypoglycaemia which resolved with the introduction of somatostatin analogue treatment and further therapeutic MIBG. However, three years later he was admitted to hospital with severe and intractable hypoglycaemia, which persisted despite treatment with dietary manipulation, diazoxide, long-acting octreotide injections, intravenous infusion of dextrose and octreotide and everolimus. Bland hepatic embolization was attempted as a last resort and resulted in prompt and dramatic improvement of his condition with no hypoglycaemia for five months. We recommend that hepatic embolization should be considered in patients with advanced and metastatic NETs accompanied by refractory hypoglycaemia, with the aim of symptomatic relief and palliation, and possibly some survival benefit.Citation
Intractable hypoglycaemia in a patient with advanced carcinoid syndrome successfully treated with hepatic embolization. 2015, 15 (1):118-21 Hormones International Journal of Endocrinology and MetabolismJournal
Hormones-International Journal of Endocrinology and MetabolismDOI
10.14310/horm.2002.1607PubMed ID
26188238Type
ArticleLanguage
enISSN
1109-3099ae974a485f413a2113503eed53cd6c53
10.14310/horm.2002.1607
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