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    Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.

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    Authors
    Møller, P
    Seppälä, T
    Bernstein, I
    Holinski-Feder, E
    Sala, P
    Evans, D Gareth R
    Lindblom, A
    Macrae, F
    Blanco, I
    Sijmons, R
    Jeffries, J
    Vasen, H
    Burn, J
    Nakken, S
    Hovig, E
    Rødland, E
    Tharmaratnam, K
    de Vos Tot Nederveen Cappel, W
    Hill, J
    Wijnen, J
    Jenkins, M
    Green, K
    Lalloo, F
    Sunde, L
    Mints, M
    Bertario, L
    Pineda, M
    Navarro, M
    Morak, M
    Renkonen-Sinisalo, L
    Frayling, I
    Plazzer, J
    Pylvanainen, K
    Genuardi, M
    Mecklin, J
    Möslein, G
    Sampson, J
    Capella, G
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    Affiliation
    Research Group Inherited Cancer, Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Issue Date
    2016-06-03
    
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    Abstract
    Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what is the cumulative incidence of a subsequent cancer; (ii) in which organs do subsequent cancers occur; and (iii) what is the survival following these cancers?
    Citation
    Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. 2016: Gut
    Journal
    Gut
    URI
    http://hdl.handle.net/10541/618173
    DOI
    10.1136/gutjnl-2016-311403
    PubMed ID
    27261338
    Type
    Article
    Language
    en
    ISSN
    1468-3288
    ae974a485f413a2113503eed53cd6c53
    10.1136/gutjnl-2016-311403
    Scopus Count
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