Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study.
Authors
Monaghan, Phillip JKyriacou, Angelos
Sturgeon, C
Davies, A
Trainer, Peter J
White, A
Higham, Claire E
Affiliation
The Christie Pathology Partnership Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UKIssue Date
2016-06-03
Metadata
Show full item recordAbstract
It is recognized that measurement of ACTH-precursor peptides including proopiomelanocortin (POMC) has clinical utility in identifying the aetiology of Cushing's syndrome. Recent data have also demonstrated cross-reactivity of POMC in ACTH immunoassays used in clinical laboratories. The aim of this study was to assess the cross-reactivity of POMC in the main commercial immunoassays for ACTH and to survey the awareness of laboratory professionals to this potential interference.Citation
Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study. 2016: Clin EndocrinolJournal
Clinical EndocrinologyDOI
10.1111/cen.13118PubMed ID
27256168Type
ArticleLanguage
enISSN
1365-2265ae974a485f413a2113503eed53cd6c53
10.1111/cen.13118