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    Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.

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    Authors
    Jahchan, N
    Lim, J
    Bola, Becky
    Morris, Karen
    Seitz, G
    Tran, Kim Q
    Xu, L
    Trapani, Francesca
    Morrow, Christopher J
    Cristea, S
    Coles, G
    Yang, D
    Vaka, D
    Kareta, M
    George, J
    Mazur, P
    Nguyen, T
    Anderson, W
    Dylla, S
    Blackhall, Fiona H
    Peifer, M
    Dive, Caroline
    Sage, J
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    Affiliation
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Issue Date
    2016-07-19
    
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    Abstract
    Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. This population, marked by high levels of EpCAM and CD24, is also prevalent in human primary SCLC tumors. Murine SCLC TPCs are numerous and highly proliferative but not intrinsically chemoresistant, indicating that not all clinical features of SCLC are linked to TPCs. SCLC TPCs possess a distinct transcriptional profile compared to non-TPCs, including elevated MYC activity. Genetic and pharmacological inhibition of MYC in SCLC cells to non-TPC levels inhibits long-term propagation but not short-term growth. These studies identify a highly tumorigenic population of SCLC cells in mouse models, cell lines, and patient tumors and a means to target them in this most fatal form of lung cancer.
    Citation
    Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer. 2016, 16 (3):644-56 Cell Rep
    Journal
    Cell Reports
    URI
    http://hdl.handle.net/10541/618168
    DOI
    10.1016/j.celrep.2016.06.021
    PubMed ID
    27373157
    Type
    Article
    Language
    en
    ISSN
    2211-1247
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.celrep.2016.06.021
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