So You Can Teach Old Fibroblasts New Tricks
| dc.contributor.author | Virós, Amaya | |
| dc.contributor.author | Girotti, Maria Romina | |
| dc.contributor.author | Marais, Richard | |
| dc.date.accessioned | 2016-07-15T15:14:16Z | |
| dc.date.available | 2016-07-15T15:14:16Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | So You Can Teach Old Fibroblasts New Tricks. 2016, 6 (6):581-3 Cancer Discov | en |
| dc.identifier.issn | 2159-8290 | |
| dc.identifier.pmid | 27261482 | |
| dc.identifier.doi | 10.1158/2159-8290.CD-16-0503 | |
| dc.identifier.uri | http://hdl.handle.net/10541/617037 | |
| dc.description.abstract | New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Cancer discovery | en |
| dc.title | So You Can Teach Old Fibroblasts New Tricks | en |
| dc.type | Article | en |
| dc.contributor.department | Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Amaya.Viros@cruk.manchester.ac.ukMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United KingdomMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom | en |
| dc.identifier.journal | Cancer Discovery | en |
| html.description.abstract | New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR. |