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    So You Can Teach Old Fibroblasts New Tricks

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    Authors
    Virós, Amaya
    Girotti, Maria Romina
    Marais, Richard
    Affiliation
    Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Amaya.Viros@cruk.manchester.ac.ukMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United KingdomMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom
    Issue Date
    2016
    
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    Abstract
    New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR.
    Citation
    So You Can Teach Old Fibroblasts New Tricks. 2016, 6 (6):581-3 Cancer Discov
    Journal
    Cancer Discovery
    URI
    http://hdl.handle.net/10541/617037
    DOI
    10.1158/2159-8290.CD-16-0503
    PubMed ID
    27261482
    Type
    Article
    Language
    en
    ISSN
    2159-8290
    ae974a485f413a2113503eed53cd6c53
    10.1158/2159-8290.CD-16-0503
    Scopus Count
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    All Paterson Institute for Cancer Research

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