Affiliation
Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Amaya.Viros@cruk.manchester.ac.ukMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United KingdomMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United KingdomIssue Date
2016
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Show full item recordAbstract
New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR.Citation
So You Can Teach Old Fibroblasts New Tricks. 2016, 6 (6):581-3 Cancer DiscovJournal
Cancer DiscoveryDOI
10.1158/2159-8290.CD-16-0503PubMed ID
27261482Type
ArticleLanguage
enISSN
2159-8290ae974a485f413a2113503eed53cd6c53
10.1158/2159-8290.CD-16-0503
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