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    Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

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    Authors
    Somerville, Tim D D
    Somervaille, Tim C P
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester , Manchester, M20 4BX
    Issue Date
    2016
    
    Metadata
    Show full item record
    Abstract
    Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.
    Citation
    Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia. 2016, 3 (2):e1131355 Mol Cell Oncol
    Journal
    Molecular & cellular oncology
    URI
    http://hdl.handle.net/10541/617027
    DOI
    10.1080/23723556.2015.1131355
    PubMed ID
    27308636
    Type
    Meetings and Proceedings
    Language
    en
    ISSN
    2372-3556
    ae974a485f413a2113503eed53cd6c53
    10.1080/23723556.2015.1131355
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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