Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia
Affiliation
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester , Manchester, M20 4BXIssue Date
2016
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Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.Citation
Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia. 2016, 3 (2):e1131355 Mol Cell OncolJournal
Molecular & cellular oncologyDOI
10.1080/23723556.2015.1131355PubMed ID
27308636Type
Meetings and ProceedingsLanguage
enISSN
2372-3556ae974a485f413a2113503eed53cd6c53
10.1080/23723556.2015.1131355
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