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dc.contributor.authorMcPartlin, Andrew J
dc.contributor.authorLi, X
dc.contributor.authorKershaw, Lucy E
dc.contributor.authorHeide, U
dc.contributor.authorKerkmeijer, L
dc.contributor.authorLawton, C
dc.contributor.authorMahmood, U
dc.contributor.authorPos, F
dc.contributor.authorvan As, N
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorVesprini, D
dc.contributor.authorvan der Voort van Zyp, J
dc.contributor.authorTree, A
dc.contributor.authorChoudhury, Ananya
dc.date.accessioned2016-06-24T12:13:56Z
dc.date.available2016-06-24T12:13:56Z
dc.date.issued2016-05-06en
dc.identifier.citationMRI-guided prostate adaptive radiotherapy - A systematic review. 2016: Radiother Oncolen
dc.identifier.issn1879-0887en
dc.identifier.pmid27162159en
dc.identifier.doi10.1016/j.radonc.2016.04.014en
dc.identifier.urihttp://hdl.handle.net/10541/614568
dc.description.abstractDose escalated radiotherapy improves outcomes for men with prostate cancer. A plateau for benefit from dose escalation using EBRT may not have been reached for some patients with higher risk disease. The use of increasingly conformal techniques, such as step and shoot IMRT or more recently VMAT, has allowed treatment intensification to be achieved whilst minimising associated increases in toxicity to surrounding normal structures. To support further safe dose escalation, the uncertainties in the treatment target position will need be minimised using optimal planning and image-guided radiotherapy (IGRT). In particular the increasing usage of profoundly hypo-fractionated stereotactic therapy is predicated on the ability to confidently direct treatment precisely to the intended target for the duration of each treatment. This article reviews published studies on the influences of varies types of motion on daily prostate position and how these may be mitigated to improve IGRT in future. In particular the role that MRI has played in the generation of data is discussed and the potential role of the MR-Linac in next-generation IGRT is discussed.
dc.languageENGen
dc.language.isoenen
dc.rightsArchived with thanks to Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen
dc.titleMRI-guided prostate adaptive radiotherapy - A systematic review.en
dc.typeArticleen
dc.contributor.departmentThe Christie NHS Foundation Trust and Manchester Cancer Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, UKen
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractDose escalated radiotherapy improves outcomes for men with prostate cancer. A plateau for benefit from dose escalation using EBRT may not have been reached for some patients with higher risk disease. The use of increasingly conformal techniques, such as step and shoot IMRT or more recently VMAT, has allowed treatment intensification to be achieved whilst minimising associated increases in toxicity to surrounding normal structures. To support further safe dose escalation, the uncertainties in the treatment target position will need be minimised using optimal planning and image-guided radiotherapy (IGRT). In particular the increasing usage of profoundly hypo-fractionated stereotactic therapy is predicated on the ability to confidently direct treatment precisely to the intended target for the duration of each treatment. This article reviews published studies on the influences of varies types of motion on daily prostate position and how these may be mitigated to improve IGRT in future. In particular the role that MRI has played in the generation of data is discussed and the potential role of the MR-Linac in next-generation IGRT is discussed.


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