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    MRI-guided prostate adaptive radiotherapy - A systematic review.

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    Authors
    McPartlin, Andrew J
    Li, X
    Kershaw, Lucy E
    Heide, U
    Kerkmeijer, L
    Lawton, C
    Mahmood, U
    Pos, F
    van As, N
    van Herk, Marcel
    Vesprini, D
    van der Voort van Zyp, J
    Tree, A
    Choudhury, Ananya
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    Affiliation
    The Christie NHS Foundation Trust and Manchester Cancer Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, UK
    Issue Date
    2016-05-06
    
    Metadata
    Show full item record
    Abstract
    Dose escalated radiotherapy improves outcomes for men with prostate cancer. A plateau for benefit from dose escalation using EBRT may not have been reached for some patients with higher risk disease. The use of increasingly conformal techniques, such as step and shoot IMRT or more recently VMAT, has allowed treatment intensification to be achieved whilst minimising associated increases in toxicity to surrounding normal structures. To support further safe dose escalation, the uncertainties in the treatment target position will need be minimised using optimal planning and image-guided radiotherapy (IGRT). In particular the increasing usage of profoundly hypo-fractionated stereotactic therapy is predicated on the ability to confidently direct treatment precisely to the intended target for the duration of each treatment. This article reviews published studies on the influences of varies types of motion on daily prostate position and how these may be mitigated to improve IGRT in future. In particular the role that MRI has played in the generation of data is discussed and the potential role of the MR-Linac in next-generation IGRT is discussed.
    Citation
    MRI-guided prostate adaptive radiotherapy - A systematic review. 2016: Radiother Oncol
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/614568
    DOI
    10.1016/j.radonc.2016.04.014
    PubMed ID
    27162159
    Type
    Article
    Language
    en
    ISSN
    1879-0887
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2016.04.014
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