Clinical experience with radium-223 in the treatment of patients with advanced castrate-resistant prostate cancer and symptomatic bone metastases.
dc.contributor.author | Hague, Christina | |
dc.contributor.author | Logue, John P | |
dc.date.accessioned | 2016-06-24T11:23:39Z | |
dc.date.available | 2016-06-24T11:23:39Z | |
dc.date.issued | 2016-06 | en |
dc.identifier.citation | Clinical experience with radium-223 in the treatment of patients with advanced castrate-resistant prostate cancer and symptomatic bone metastases. 2016, 8 (3):175-80 Ther Adv Urol | en |
dc.identifier.issn | 1756-2872 | en |
dc.identifier.pmid | 27247627 | en |
dc.identifier.doi | 10.1177/1756287216629870 | en |
dc.identifier.uri | http://hdl.handle.net/10541/614557 | |
dc.description.abstract | The treatment of metastatic castrate-resistant prostate cancer (mCRPC) has grown over the past decade. The majority of patients develop bone metastases, which pose a significant burden on morbidity and mortality, especially skeletal-related events. Whilst demonstrating a favourable safety profile and improving symptoms, radiopharmaceuticals have until recently failed to show a survival benefit. However, since the large phase III randomized ALSYMPCA trial, the calcium mimetic properties of radium-223 (Ra223) have improved patients' quality of life and improved survival whilst keeping toxicities to a minimum. This review article summarizes the clinical data including our real life experience on the usage of the alpha emitter Ra223 in mCRPC, paying particular attention to how clinicians should best monitor response. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Therapeutic advances in urology | en |
dc.title | Clinical experience with radium-223 in the treatment of patients with advanced castrate-resistant prostate cancer and symptomatic bone metastases. | en |
dc.type | Article | en |
dc.contributor.department | Department of Clinical Oncology, The Christie NHS Foundation Trust, Wimslow Road, Manchester M20 4BX | en |
dc.identifier.journal | Therapeutic Advances in Urology | en |
html.description.abstract | The treatment of metastatic castrate-resistant prostate cancer (mCRPC) has grown over the past decade. The majority of patients develop bone metastases, which pose a significant burden on morbidity and mortality, especially skeletal-related events. Whilst demonstrating a favourable safety profile and improving symptoms, radiopharmaceuticals have until recently failed to show a survival benefit. However, since the large phase III randomized ALSYMPCA trial, the calcium mimetic properties of radium-223 (Ra223) have improved patients' quality of life and improved survival whilst keeping toxicities to a minimum. This review article summarizes the clinical data including our real life experience on the usage of the alpha emitter Ra223 in mCRPC, paying particular attention to how clinicians should best monitor response. |