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    An adaptive study to determine the optimal dose of the tablet formulation of the PARP inhibitor olaparib.

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    Authors
    Mateo, J
    Moreno, V
    Gupta, A
    Kaye, S
    Dean, Emma J
    Middleton, M
    Friedlander, M
    Gourley, C
    Plummer, R
    Rustin, G
    Sessa, C
    Leunen, K
    Ledermann, J
    Swaisland, H
    Fielding, A
    Bannister, W
    Nicum, S
    Molife, L
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    Affiliation
    Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Downs Road, Sutton, SM2 5PT, UK
    Issue Date
    2016-06
    
    Metadata
    Show full item record
    Abstract
    Olaparib is poorly soluble, requiring advanced drug delivery technologies for adequate bioavailability. Sixteen capsules/day are required for the approved 400 mg twice-daily dose; a tablet formulation was developed to reduce pill burden. This clinical trial evaluated the optimal dose and administration schedule of the tablet formulation.
    Citation
    An adaptive study to determine the optimal dose of the tablet formulation of the PARP inhibitor olaparib. 2016, 11 (3):401-15 Target Oncol
    Journal
    Targeted Oncology
    URI
    http://hdl.handle.net/10541/614533
    DOI
    10.1007/s11523-016-0435-8
    PubMed ID
    27169564
    Type
    Article
    Language
    en
    ISSN
    1776-260X
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11523-016-0435-8
    Scopus Count
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