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    Cancer stem cell metabolism.

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    Authors
    Peiris-Pagès, Maria
    Martinez-Outschoorn, U
    Pestell, R
    Sotgia, F
    Lisanti, Michael P
    Affiliation
    The Breast Cancer Now Research Unit, Institute of Cancer Sciences, CRUK Manchester Institute, Paterson Building, University of Manchester, Manchester
    Issue Date
    2016
    
    Metadata
    Show full item record
    Abstract
    Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
    Citation
    Cancer stem cell metabolism. 2016, 18 (1):55 Breast Cancer Res
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/614532
    DOI
    10.1186/s13058-016-0712-6
    PubMed ID
    27220421
    Type
    Article
    Language
    en
    ISSN
    1465-542X
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13058-016-0712-6
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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