Consensus on precision medicine for metastatic cancers: A report from the MAP conference.
Authors
Swanton, CSoria, J
Bardelli, A
Biankin, A
Caldas, C
Chandarlapaty, S
de Koning, L
Dive, Caroline
Feunteun, J
Leung, S
Marais, Richard
Mardis, E
McGranahan, N
Middleton, G
Quezada, S
Rodón, J
Rosenfeld, N
Sotiriou, C
André, F
Affiliation
Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, LondonIssue Date
2016-05-03
Metadata
Show full item recordAbstract
Recent advances in biotechnologies have led to the development of multiplex genomic and proteomic analyses for clinical use. Nevertheless, guidelines are currently lacking to determine which molecular assays should be implemented in metastatic cancers. The 1(st) MAP conference was dedicated to exploring the use of genomics to better select therapies in the treatment of metastatic cancers. 16 consensus items were covered. While there was a consensus that new technologies like next-generation sequencing (NGS) of tumors and of ddPCR on circulating free DNA have convincing analytical validity, further work needs to be undertaken to establish both the clinical utility of liquid biopsies and the added clinical value of expanding from individual gene tests into large gene panels. Experts agreed that standardized bioinformatics methods for biological interpretation of genomic data are needed and that Precision Medicine trials should be stratified based on the level of evidence available for the genomic alterations identified.Citation
Consensus on precision medicine for metastatic cancers: A report from the MAP conference. 2016: Ann OncolJournal
Annals of OncologyDOI
10.1093/annonc/mdw192PubMed ID
27143638Type
ArticleLanguage
enISSN
1569-8041ae974a485f413a2113503eed53cd6c53
10.1093/annonc/mdw192