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dc.contributor.authorCree, I
dc.contributor.authorBooton, R
dc.contributor.authorCane, P
dc.contributor.authorGosney, J
dc.contributor.authorIbrahim, M
dc.contributor.authorKerr, K
dc.contributor.authorLal, R
dc.contributor.authorLewanski, C
dc.contributor.authorNavani, N
dc.contributor.authorNicholson, A
dc.contributor.authorNicolson, M
dc.contributor.authorSummers, Yvonne J
dc.date.accessioned2016-06-16T10:47:15Zen
dc.date.available2016-06-16T10:47:15Zen
dc.date.issued2016-05-19en
dc.identifier.citationPD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. 2016: Histopathologyen
dc.identifier.issn1365-2559en
dc.identifier.pmid27196116en
dc.identifier.doi10.1111/his.12996en
dc.identifier.urihttp://hdl.handle.net/10541/613327en
dc.description.abstractA new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1). Several drugs have been approved or are in the late stages of development targeting PD-1 (pembrolizumab and nivolumab) or PD-L1 (atezolizumab, durvalumab and avelumab). Inevitably, the introduction of these drugs will place pressure on healthcare systems and there is a need to stratify patients to identify those who are most likely to benefit from such treatment. There is evidence that responsiveness to PD-1 inhibitors may be predicted by expression of PD-L1 on neoplastic cells. Hence, there is considerable interest in using PD-L1 immunohistochemical staining to guide the use of PD-1-targeted treatments in patients with NSCLC. This paper reviews the current knowledge about PD-L1 testing and identifies current research requirements. Key factors to consider include the source and timing of sample collection, pre-analytical steps (sample tracking, fixation, tissue processing, sectioning and tissue prioritization), analytical decisions (choice of biomarker assay/kit and automated staining platform, with verification of standardized assays or validation of laboratory-devised techniques, internal and external quality assurance and audit), and reporting and interpretation of the results. This review addresses the need for integration of PD-L1 immunohistochemistry with other tests as part of locally agreed pathways and protocols. There remain areas of uncertainty and guidance should be updated regularly as new information becomes available. This article is protected by copyright. All rights reserved.
dc.languageENGen
dc.language.isoenen
dc.rightsArchived with thanks to Histopathologyen
dc.titlePD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University Hospitals Coventry and Warwickshire NHS Trust, Coventryen
dc.identifier.journalHistopathologyen
html.description.abstractA new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1). Several drugs have been approved or are in the late stages of development targeting PD-1 (pembrolizumab and nivolumab) or PD-L1 (atezolizumab, durvalumab and avelumab). Inevitably, the introduction of these drugs will place pressure on healthcare systems and there is a need to stratify patients to identify those who are most likely to benefit from such treatment. There is evidence that responsiveness to PD-1 inhibitors may be predicted by expression of PD-L1 on neoplastic cells. Hence, there is considerable interest in using PD-L1 immunohistochemical staining to guide the use of PD-1-targeted treatments in patients with NSCLC. This paper reviews the current knowledge about PD-L1 testing and identifies current research requirements. Key factors to consider include the source and timing of sample collection, pre-analytical steps (sample tracking, fixation, tissue processing, sectioning and tissue prioritization), analytical decisions (choice of biomarker assay/kit and automated staining platform, with verification of standardized assays or validation of laboratory-devised techniques, internal and external quality assurance and audit), and reporting and interpretation of the results. This review addresses the need for integration of PD-L1 immunohistochemistry with other tests as part of locally agreed pathways and protocols. There remain areas of uncertainty and guidance should be updated regularly as new information becomes available. This article is protected by copyright. All rights reserved.


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