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    Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.

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    Authors
    Ferreri, A
    Cwynarski, K
    Pulczynski, E
    Ponzoni, M
    Deckert, M
    Politi, L
    Torri, V
    Fox, C
    Rosée, P
    Schorb, E
    Ambrosetti, A
    Roth, A
    Hemmaway, C
    Ferrari, A
    Linton, Kim M
    Rudà, R
    Binder, M
    Pukrop, T
    Balzarotti, M
    Fabbri, A
    Johnson, P
    Gørløv, J
    Hess, G
    Panse, J
    Pisani, F
    Tucci, A
    Stilgenbauer, S
    Hertenstein, B
    Keller, U
    Krause, S
    Levis, A
    Schmoll, H
    Cavalli, F
    Finke, J
    Reni, M
    Zucca, E
    Illerhaus, G
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    Affiliation
    Unit of Lymphoid Malignancies, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy
    Issue Date
    2016-05
    
    Metadata
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    Abstract
    Standard treatment for patients with primary CNS lymphoma remains to be defined. Active therapies are often associated with increased risk of haematological or neurological toxicity. In this trial, we addressed the tolerability and efficacy of adding rituximab with or without thiotepa to methotrexate-cytarabine combination therapy (the MATRix regimen), followed by a second randomisation comparing consolidation with whole-brain radiotherapy or autologous stem cell transplantation in patients with primary CNS lymphoma. We report the results of the first randomisation in this Article.
    Citation
    Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial. 2016, 3 (5):e217-27 Lancet Haematol
    Journal
    The Lancet Haematology
    URI
    http://hdl.handle.net/10541/610746
    DOI
    10.1016/S2352-3026(16)00036-3
    PubMed ID
    27132696
    Type
    Article
    Language
    en
    ISSN
    2352-3026
    ae974a485f413a2113503eed53cd6c53
    10.1016/S2352-3026(16)00036-3
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