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    Potential clinical utility of copeptin (C-terminal provasopressin) measurements in clinical medicine.

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    Authors
    Lewandowski, K
    Brabant, G E
    Affiliation
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
    Issue Date
    2016-03
    
    Metadata
    Show full item record
    Abstract
    Copeptin is a 39-amino-acids containing glycosylated peptide derived from the C-terminal part of the arginine vasopressin (AVP) precursor. In the process of proteolysis the AVP precursor is processed to AVP, neurophysin II, and copeptin in equimolar amounts. In contrast to AVP, copeptin remains stable for several days at room temperature in serum or plasma. Hence, copeptin serves as a bona fide biomarker of AVP release. We briefly summarise clinical utility of copeptin in the diagnosis of diabetes insipidus. We also discuss potential applications of copeptin measurements in hyponatraemic states, assessment of an anterior pituitary function, as well as a wide range of several acute and chronic medical conditions, such as myocardial infarction, stroke or diabetes mellitus.
    Citation
    Potential clinical utility of copeptin (C-terminal provasopressin) measurements in clinical medicine. 2016, 124 (3):173-7 Exp. Clin. Endocrinol. Diabetes
    Journal
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
    URI
    http://hdl.handle.net/10541/610745
    DOI
    10.1055/s-0035-1569341
    PubMed ID
    27008633
    Type
    Article
    Language
    en
    ISSN
    1439-3646
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-0035-1569341
    Scopus Count
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