Affiliation
Cell Signaling Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester , UKIssue Date
2016-04-22
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Show full item recordAbstract
In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers. Moreover, the effects of ablating genes encoding Rho GTPases and their regulators in mouse models, or through pharmacological inhibition, strongly suggests that targeting Rho GTPase signaling could constitute an effective treatment. In this review we will explore the various ways in which Rho signaling can be deregulated in human cancers.Citation
Deregulation of Rho GTPases in cancer. 2016:1-16 Small GTPasesJournal
Small GTPasesDOI
10.1080/21541248.2016.1173767PubMed ID
27104658Type
ArticleLanguage
enISSN
2154-1256ae974a485f413a2113503eed53cd6c53
10.1080/21541248.2016.1173767
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