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    Deregulation of Rho GTPases in cancer.

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    Authors
    Porter, Andrew P
    Papaioannou, Alexandra
    Malliri, Angeliki
    Affiliation
    Cell Signaling Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester , UK
    Issue Date
    2016-04-22
    
    Metadata
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    Abstract
    In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers. Moreover, the effects of ablating genes encoding Rho GTPases and their regulators in mouse models, or through pharmacological inhibition, strongly suggests that targeting Rho GTPase signaling could constitute an effective treatment. In this review we will explore the various ways in which Rho signaling can be deregulated in human cancers.
    Citation
    Deregulation of Rho GTPases in cancer. 2016:1-16 Small GTPases
    Journal
    Small GTPases
    URI
    http://hdl.handle.net/10541/610719
    DOI
    10.1080/21541248.2016.1173767
    PubMed ID
    27104658
    Type
    Article
    Language
    en
    ISSN
    2154-1256
    ae974a485f413a2113503eed53cd6c53
    10.1080/21541248.2016.1173767
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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